› 1nhl

X-ray diffraction
2.3Å resolution

SNAP-23N Structure

Released:
DOI: 10.2210/pdb1nhl/pdb
PDB entry 1nhl coloured by chain, front view.
PDB entry 1nhl coloured by chain, side view.
PDB entry 1nhl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain.
Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ
J Biol Chem 278 13462-7 (2003)
PMID: 12556468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-126126 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptosomal-associated protein 23 Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 6.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00161 (Residues: 23-76; Coverage: 26%)
Gene name: SNAP23
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P4212
Unit cell:
a: 34.905Å b: 34.905Å c: 81.691Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.281 0.273 0.316
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials.
Apostolovic et al. (2010)
1 more

3 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
2 more