› 1ny9

Solution NMR

Antibiotic binding domain of a TipA-class multidrug resistance transcriptional regulator

Released:
DOI: 10.2210/pdb1ny9/pdb
PDB entry 1ny9 coloured by chain, ensemble of 10 models, front view.
PDB entry 1ny9 coloured by chain, ensemble of 10 models, side view.
PDB entry 1ny9 coloured by chain, ensemble of 10 models, top view.
Source organism: Streptomyces lividans
Primary publication:
Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators.
Kahmann JD, Sass HJ, Allan MG, Seto H, Thompson CJ, Grzesiek S
EMBO J 22 1824-34 (2003)
PMID: 12682015

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141264 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional activator TipA Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 16.45 KDa
Source organism: Streptomyces lividans
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A4T9 (Residues: 111-253; Coverage: 57%)
Gene name: tipA
Sequence domains: TipAS antibiotic-recognition domain
Structure domains: Antibiotic binding domain of TipA-like multidrug resistance regulators

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing with torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

8 review citations

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.
Burkhart et al. (2017)
7 more

4 mentions without citation

Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators.
Kahmann et al. (2003)
3 more