› 1p15

X-ray diffraction
2Å resolution

Crystal structure of the D2 domain of RPTPa

Released:
DOI: 10.2210/pdb1p15/pdb
PDB entry 1p15 coloured by chain, front view.
PDB entry 1p15 coloured by chain, side view.
PDB entry 1p15 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region.
Sonnenburg ED, Bilwes A, Hunter T, Noel JP
Biochemistry 42 7904-14 (2003)
PMID: 12834342

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148272 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 253 amino acids
Theoretical weight: 29.25 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18052 (Residues: 577-829; Coverage: 31%)
Gene names: Lrp, Ptpa, Ptpra
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P31
Unit cell:
a: 59.101Å b: 59.101Å c: 152.657Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.203 0.255
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Src kinase regulation by phosphorylation and dephosphorylation.
Roskoski R. (2005)
6 more

2 mentions without citation

Evaluation of two homologous proline-rich proteins of Coccidioides posadasii as candidate vaccines against coccidioidomycosis.
Herr et al. (2007)
1 more