› 1pbq

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1pbq/pdb
PDB entry 1pbq coloured by chain, front view.
PDB entry 1pbq coloured by chain, side view.
PDB entry 1pbq coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
Furukawa H, Gouaux E
EMBO J 22 2873-85 (2003)
PMID: 12805203

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152906 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35439 (Residues: 394-800; Coverage: 32%)
Gene names: Grin1, Nmdar1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand DK1 2 x DK1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 85.7Å b: 65.3Å c: 124.3Å
α: 90° β: 98.1° γ: 90°
R-values:
R R work R free
0.231 0.231 0.27
Expression system: Escherichia coli

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Citations

75 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
74 more

24 mentions without citation

Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches.
Cruz-Vicente et al. (2021)
23 more