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Solution NMR

STRUCTURE OF THE PI3K SH3 DOMAIN AND ANALYSIS OF THE SH3 FAMILY

Released:
DOI: 10.2210/pdb1pks/pdb
PDB entry 1pks coloured by chain, front view.
PDB entry 1pks coloured by chain, side view.
PDB entry 1pks coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the PI3K SH3 domain and analysis of the SH3 family.
Koyama S, Yu H, Dalgarno DC, Shin TB, Zydowsky LD, Schreiber SL
Cell 72 945-52 (1993)
PMID: 7681364

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P27986 (Residues: 1-79; Coverage: 11%)
Gene names: GRB1, PIK3R1
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

19 review citations

Protein-protein interactions: methods for detection and analysis.
Phizicky et al. (1995)
18 more

7 mentions without citation

Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains?
Erickson HP. (2017)
6 more