› 1pp2

X-ray diffraction
2.5Å resolution

THE REFINED CRYSTAL STRUCTURE OF DIMERIC PHOSPHOLIPASE A2 AT 2.5 ANGSTROMS. ACCESS TO A SHIELDED CATALYTIC CENTER

Released:
DOI: 10.2210/pdb1pp2/pdb
PDB entry 1pp2 coloured by chain, front view.
PDB entry 1pp2 coloured by chain, side view.
PDB entry 1pp2 coloured by chain, top view.
Source organism: Crotalus atrox
Primary publication:
The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center.
Brunie S, Bolin J, Gewirth D, Sigler PB
J Biol Chem 260 9742-9 (1985)
PMID: 4019493

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 Chains: L, R
Molecule details ›
Chains: L, R
Length: 122 amino acids
Theoretical weight: 13.61 KDa
Source organism: Crotalus atrox
Expression system: Not provided
UniProt:
  • Canonical: P00624 (Residues: 17-138; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 53.4Å b: 100.2Å c: 48.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 not available not available
Expression system: Not provided

Quick links

Citations

6 review citations

Phospholipase A2 myotoxins from Bothrops snake venoms.
Gutiérrez et al. (1995)
5 more

7 mentions without citation

Bioactive Molecules Derived from Snake Venoms with Therapeutic Potential for the Treatment of Thrombo-Cardiovascular Disorders Associated with COVID-19.
Chérifi et al. (2021)
6 more