› 1pvj

X-ray diffraction
3Å resolution

Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex

Released:
DOI: 10.2210/pdb1pvj/pdb
PDB entry 1pvj coloured by chain, front view.
PDB entry 1pvj coloured by chain, side view.
PDB entry 1pvj coloured by chain, top view.
Source organism: Streptococcus pyogenes
Entry authors: Ziomek E, Sivaraman J, Doran J, Menard R, Cygler M

Function and Biology Details

Reaction catalysed: 
Preferential cleavage with hydrophobic residues at P2, P1 and P1'.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142886 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Streptopain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 368 amino acids
Theoretical weight: 40.02 KDa
Source organism: Streptococcus pyogenes
UniProt:
  • Canonical: P0C0J0 (Residues: 31-398; Coverage: 99%)
Gene name: speB
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZFB 4 x ZFB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 95.769Å b: 119.495Å c: 144.083Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.288

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