› 1qad

X-ray diffraction
1.8Å resolution

Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of Phosphoinositide 3-Kinase: An SH2 domain mimicking its own substrate

Released:
DOI: 10.2210/pdb1qad/pdb
PDB entry 1qad coloured by chain, front view.
PDB entry 1qad coloured by chain, side view.
PDB entry 1qad coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate.
Hoedemaeker FJ, Siegal G, Roe SM, Driscoll PC, Abrahams JP
J Mol Biol 292 763-70 (1999)
PMID: 10525402

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.62 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P23727 (Residues: 614-724; Coverage: 15%)
Gene name: PIK3R1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P212121
Unit cell:
a: 38.68Å b: 46.92Å c: 62.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.158 0.236
Expression system: Not provided

Quick links

Citations

2 review citations

The regulation of class IA PI 3-kinases by inter-subunit interactions.
Backer JM. (2010)
1 more

3 mentions without citation

Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design.
Gabelli et al. (2010)
2 more