Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Importin complex, KPNA2 variant (preferred)
PDBe Complex ID:
PDB-CPX-156495 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit beta-1
Molecule details ›
Chain: A
Length: 876 amino acids
Theoretical weight: 97.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Length: 876 amino acids
Theoretical weight: 97.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q14974 (Residues: 1-876; Coverage: 100%)
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Importin subunit alpha-1
Molecule details ›
Chain: B
Length: 44 amino acids
Theoretical weight: 5.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Importin beta binding domain
Structure domains: Importin-alpha, importin-beta-binding domain
Length: 44 amino acids
Theoretical weight: 5.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P52292 (Residues: 11-54; Coverage: 8%)
Sequence domains: Importin beta binding domain
Structure domains: Importin-alpha, importin-beta-binding domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID2
Spacegroup:
P21
Expression systems:
- Escherichia coli
- Not provided
