› 1qmv

X-ray diffraction
1.7Å resolution

thioredoxin peroxidase B from red blood cells

Released:
DOI: 10.2210/pdb1qmv/pdb
PDB entry 1qmv coloured by chain, front view.
PDB entry 1qmv coloured by chain, side view.
PDB entry 1qmv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution.
Schröder E, Littlechild JA, Lebedev AA, Errington N, Vagin AA, Isupov MN
Structure 8 605-15 (2000)
PMID: 10873855

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-2 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 197 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P32119 (Residues: 2-198; Coverage: 100%)
Gene names: NKEFB, PRDX2, TDPX1
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
2 modified residues:
Ligand NCB 10 x NCB
Ligand CSD 10 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 88.88Å b: 107.03Å c: 119.5Å
α: 90° β: 110.87° γ: 90°
R-values:
R R work R free
0.192 0.192 0.256

Quick links

Citations

53 review citations

Structure, mechanism and regulation of peroxiredoxins.
Wood et al. (2003)
52 more

63 mentions without citation

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
Hall et al. (2009)
62 more