› 1qua

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF ACUTOLYSIN-C, A HEMORRHAGIC TOXIN FROM THE SNAKE VENOM OF AGKISTRODON ACUTUS, AT 2.2 A RESOLUTION

Released:
DOI: 10.2210/pdb1qua/pdb
PDB entry 1qua coloured by chain, front view.
PDB entry 1qua coloured by chain, side view.
PDB entry 1qua coloured by chain, top view.
Source organism: Deinagkistrodon acutus
Primary publication:
Structure of acutolysin-C, a haemorrhagic toxin from the venom of Agkistrodon acutus, providing further evidence for the mechanism of the pH-dependent proteolytic reaction of zinc metalloproteinases.
Zhu X, Teng M, Niu L
Acta Crystallogr D Biol Crystallogr 55 1834-41 (1999)
PMID: 10531480

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase acutolysin-C Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 21.46 KDa
Source organism: Deinagkistrodon acutus
UniProt:
  • Canonical: P60244 (Residues: 1-197; Coverage: 100%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P212121
Unit cell:
a: 46.838Å b: 49.524Å c: 95.343Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.176 0.272

Quick links

Citations

5 review citations

Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity.
Fox et al. (2008)
4 more

6 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
5 more