Function and Biology Details
Reaction catalysed:
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP), synaptosome-associated protein of 25 kDa (SNAP25) or syntaxin. No detected action on small molecule substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Botulinum/Tetanus toxin, catalytic chain
- Clostridium neurotoxin, translocation domain
- Kunitz inhibitor STI-like superfamily
- Clostridium neurotoxin, receptor-binding C-terminal
- Clostridium neurotoxin, receptor binding N-terminal
- Concanavalin A-like lectin/glucanase domain superfamily
- Clostridium neurotoxin, translocation
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Botulinum neurotoxin type B (preferred)
PDBe Complex ID:
PDB-CPX-145485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Botulinum neurotoxin type B
Molecule details ›
Chain: A
Length: 1290 amino acids
Theoretical weight: 150.83 KDa
Source organism: Clostridium botulinum
UniProt:
Sequence domains:
Length: 1290 amino acids
Theoretical weight: 150.83 KDa
Source organism: Clostridium botulinum
UniProt:
- Canonical:
P10844 (Residues: 2-1291; Coverage: 100%)
Sequence domains:
- Clostridial neurotoxin zinc protease
- Clostridium neurotoxin, Translocation domain
- Clostridium neurotoxin, N-terminal receptor binding
- Clostridium neurotoxin, C-terminal receptor binding
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X25
Spacegroup:
P21
