› 1s9p

X-ray diffraction
2.13Å resolution

crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with diethylstilbestrol

Released:
DOI: 10.2210/pdb1s9p/pdb
PDB entry 1s9p coloured by chain, front view.
PDB entry 1s9p coloured by chain, side view.
PDB entry 1s9p coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.
Greschik H, Flaig R, Renaud JP, Moras D
J Biol Chem 279 33639-46 (2004)
PMID: 15161930

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 227 amino acids
Theoretical weight: 25.79 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62509 (Residues: 232-458; Coverage: 50%)
Gene names: Err3, Esrrg, Kiaa0832, Nr3b3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand DES 4 x DES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 71.999Å b: 77.46Å c: 95.773Å
α: 90° β: 97.55° γ: 90°
R-values:
R R work R free
0.226 0.226 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Overview of nomenclature of nuclear receptors.
Germain et al. (2006)
20 more

3 mentions without citation

A structural signature motif enlightens the origin and diversification of nuclear receptors.
Beinsteiner et al. (2021)
2 more