› 1s9q

X-ray diffraction
2.2Å resolution

crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4-hydroxytamoxifen

Released:
DOI: 10.2210/pdb1s9q/pdb
PDB entry 1s9q coloured by chain, front view.
PDB entry 1s9q coloured by chain, side view.
PDB entry 1s9q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.
Greschik H, Flaig R, Renaud JP, Moras D
J Biol Chem 279 33639-46 (2004)
PMID: 15161930

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen-related receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 28.39 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62509 (Residues: 229-456; Coverage: 50%)
Gene names: Err3, Esrrg, Kiaa0832, Nr3b3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand OHT 2 x OHT
Ligand CHD 2 x CHD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P4322
Unit cell:
a: 89.481Å b: 89.481Å c: 161.761Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.244
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Overview of nomenclature of nuclear receptors.
Germain et al. (2006)
20 more

1 mention without citation

Four-dimensional docking: a fast and accurate account of discrete receptor flexibility in ligand docking.
Bottegoni et al. (2009)