› 1tdv

X-ray diffraction
1.7Å resolution

Non-specific binding to phospholipase A2:Crystal structure of the complex of PLA2 with a designed peptide Tyr-Trp-Ala-Ala-Ala-Ala at 1.7A resolution

Released:
DOI: 10.2210/pdb1tdv/pdb
PDB entry 1tdv coloured by chain, front view.
PDB entry 1tdv coloured by chain, side view.
PDB entry 1tdv coloured by chain, top view.
Source organism: Daboia russelii pulchella
Entry authors: Singh N, Jabeen T, Ethayathulla AS, Somvanshi RK, Sharma S, Dey S, Perbandt M, Betzel C, Singh TP

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157753 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Basic phospholipase A2 VRV-PL-VIIIa Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.63 KDa
Source organism: Daboia russelii pulchella
UniProt:
  • Canonical: P59071 (Residues: 1-121; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain
YWAAAA Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 652 Da
Source organism: Daboia russelii pulchella
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P43
Unit cell:
a: 52.29Å b: 52.29Å c: 47.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.206
Expression system: Not provided

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