› 1tye

X-ray diffraction
2.9Å resolution

Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen

Released:
DOI: 10.2210/pdb1tye/pdb
PDB entry 1tye coloured by chain, front view.
PDB entry 1tye coloured by chain, side view.
PDB entry 1tye coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
Xiao T, Takagi J, Coller BS, Wang JH, Springer TA
Nature 432 59-67 (2004)
PMID: 15378069

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138441 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Integrin alpha-IIb heavy chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 452 amino acids
Theoretical weight: 49.04 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08514 (Residues: 32-483; Coverage: 45%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal
Integrin beta-3 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 440 amino acids
Theoretical weight: 48.72 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05106 (Residues: 27-466; Coverage: 58%)
Gene names: GP3A, ITGB3
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer
4 bound ligands:
Ligand CA 18 x CA
Ligand NAG 7 x NAG
Ligand CAC 3 x CAC
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P62
Unit cell:
a: 332.093Å b: 332.093Å c: 88.288Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.268 0.219 0.254
Expression system: Cricetulus griseus

Quick links

Citations

112 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
111 more

6 mentions without citation

The tail of integrin activation.
Anthis et al. (2011)
5 more