1u8l

X-ray diffraction
2.6Å resolution

Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide DLDRWAS

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211578 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ANTIBODY 2F5 (LIGHT CHAIN) Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
ANTIBODY 2F5 (HEAVY CHAIN) Chain: B
Molecule details ›
Chain: B
Length: 235 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
GP41 PEPTIDE Chain: C
Molecule details ›
Chain: C
Length: 7 amino acids
Theoretical weight: 863 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 58Å b: 65Å c: 175.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.249
Expression system: Not provided