› 1ub7

X-ray diffraction
2.3Å resolution

The Crystal Analysis of Beta-Keroacyl-[Acyl Carrier Protein] Synthase III (FABH)From Thermus Thermophilus.

Released:
DOI: 10.2210/pdb1ub7/pdb
PDB entry 1ub7 coloured by chain, front view.
PDB entry 1ub7 coloured by chain, side view.
PDB entry 1ub7 coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Entry authors: Inagaki E, Miyano M, Tahirov TH, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181930 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-ketoacyl-[acyl-carrier-protein] synthase III Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 322 amino acids
Theoretical weight: 34.57 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7SI99 (Residues: 1-322; Coverage: 100%)
Gene names: TthAA11_04480, TthHB5018_04250, fabH
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand GOL 10 x GOL
1 modified residue:
Ligand CSO 4 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44B2
Spacegroup: P21
Unit cell:
a: 57.586Å b: 91.355Å c: 149.436Å
α: 90° β: 98.26° γ: 90°
R-values:
R R work R free
0.193 0.193 0.241
Expression system: Escherichia coli BL21(DE3)

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