› 1vso

X-ray diffraction
1.85Å resolution

Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex With the Antagonist (S)-ATPO at 1.85 A resolution

Released:
DOI: 10.2210/pdb1vso/pdb
PDB entry 1vso coloured by chain, front view.
PDB entry 1vso coloured by chain, side view.
PDB entry 1vso coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
Hald H, Naur P, Pickering DS, Sprogøe D, Madsen U, Timmermann DB, Ahring PK, Liljefors T, Schousboe A, Egebjerg J, Gajhede M, Kastrup JS
J Biol Chem 282 25726-36 (2007)
PMID: 17581823

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 29.11 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 445-559, 682-820; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand AT1 1 x AT1
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P64
Unit cell:
a: 108.9Å b: 108.9Å c: 51.092Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.202 0.231
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
8 more

14 mentions without citation

Directory of useful decoys, enhanced (DUD-E): better ligands and decoys for better benchmarking.
Mysinger et al. (2012)
13 more