Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Coagulation factor VIIa complex (preferred)
PDBe Complex ID:
PDB-CPX-140351 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor VII heavy chain
Molecule details ›
Chain: H
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P08709 (Residues: 213-466; Coverage: 57%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor VII light chain
Molecule details ›
Chain: L
Length: 55 amino acids
Theoretical weight: 6.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
Length: 55 amino acids
Theoretical weight: 6.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P08709 (Residues: 150-204; Coverage: 12%)
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
