› 1xfe

Solution NMR

Solution structure of the LA7-EGFA pair from the LDL receptor

Released:
DOI: 10.2210/pdb1xfe/pdb
PDB entry 1xfe coloured by chain, ensemble of 15 models, front view.
PDB entry 1xfe coloured by chain, ensemble of 15 models, side view.
PDB entry 1xfe coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor.
Beglova N, Jeon H, Fisher C, Blacklow SC
Mol Cell 16 281-92 (2004)
PMID: 15494314

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01130 (Residues: 272-353; Coverage: 10%)
Gene name: LDLR
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

Structure and physiologic function of the low-density lipoprotein receptor.
Jeon et al. (2005)
10 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)