› 1xzz

X-ray diffraction
1.8Å resolution

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor

Released:
DOI: 10.2210/pdb1xzz/pdb
PDB entry 1xzz coloured by chain, front view.
PDB entry 1xzz coloured by chain, side view.
PDB entry 1xzz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor.
Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M
Mol Cell 17 193-203 (2005)
PMID: 15664189

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 27.42 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11881 (Residues: 2-223; Coverage: 8%)
  • Best match: P11881-3 (Residues: 2-223)
Gene names: Insp3r, Itpr1, Pcd6, Pcp1
Sequence domains: Inositol 1,4,5-trisphosphate/ryanodine receptor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: R32
Unit cell:
a: 147.3Å b: 147.3Å c: 65Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.205 0.238
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Inositol trisphosphate receptor Ca2+ release channels.
Foskett et al. (2007)
27 more

15 mentions without citation

Gating machinery of InsP3R channels revealed by electron cryomicroscopy.
Fan et al. (2015)
14 more