› 1y8d

Solution NMR

Dimeric parallel-stranded tetraplex with 3+1 5' G-tetrad interface, single-residue chain reversal loops and GAG triad in the context of A(GGGG) pentad

Released:
DOI: 10.2210/pdb1y8d/pdb
PDB entry 1y8d coloured by chain, ensemble of 10 models, front view.
PDB entry 1y8d coloured by chain, ensemble of 10 models, side view.
PDB entry 1y8d coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase.
Phan AT, Kuryavyi V, Ma JB, Faure A, Andréola ML, Patel DJ
Proc Natl Acad Sci U S A 102 634-9 (2005)
PMID: 15637158

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114844 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*GP*GP*GP*TP*GP*GP*GP*AP*GP*GP*AP*GP*GP*GP*T)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 16 nucleotides
Theoretical weight: 5.14 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry; simulated annealing; molecular dynamics; matrix relaxation
Expression system: Not provided

Quick links

Citations

23 review citations

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
22 more

8 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
7 more