› 1z78

X-ray diffraction
1.8Å resolution

Crystal Structure of the Thrombospondin-1 N-terminal domain

Released:
DOI: 10.2210/pdb1z78/pdb
PDB entry 1z78 coloured by chain, front view.
PDB entry 1z78 coloured by chain, side view.
PDB entry 1z78 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin.
Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J
Structure 14 33-42 (2006)
PMID: 16407063

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thrombospondin-1 Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 23.6 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P07996 (Residues: 19-233; Coverage: 19%)
Gene names: THBS1, TSP, TSP1
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 42.812Å b: 41.899Å c: 53.458Å
α: 90° β: 100.649° γ: 90°
R-values:
R R work R free
0.253 0.236 0.259
Expression system: Drosophila melanogaster

Quick links

Citations

8 review citations

The structure of glycosaminoglycans and their interactions with proteins.
Gandhi et al. (2008)
7 more

7 mentions without citation

Structures of thrombospondins.
Carlson et al. (2008)
6 more