› 2a20

Solution NMR

Solution structure of Rim2 Zinc Finger Domain

Released:
DOI: 10.2210/pdb2a20/pdb
PDB entry 2a20 coloured by chain, ensemble of 20 models, front view.
PDB entry 2a20 coloured by chain, ensemble of 20 models, side view.
PDB entry 2a20 coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
Dulubova I, Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Südhof TC, Rizo J
EMBO J 24 2839-50 (2005)
PMID: 16052212

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulating synaptic membrane exocytosis protein 2 Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 6.87 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9JIS1 (Residues: 83-142; Coverage: 4%)
Gene names: Rim2, Rims2
Sequence domains: RIM2-alpha zinc finger
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

61 review citations

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.
Muoio et al. (2008)
60 more

3 mentions without citation

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
Dulubova et al. (2005)
2 more