› 2aeb

X-ray diffraction
1.29Å resolution

Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.

Released:
DOI: 10.2210/pdb2aeb/pdb
PDB entry 2aeb coloured by chain, front view.
PDB entry 2aeb coloured by chain, side view.
PDB entry 2aeb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.
Di Costanzo L, Sabio G, Mora A, Rodriguez PC, Ochoa AC, Centeno F, Christianson DW
Proc Natl Acad Sci U S A 102 13058-63 (2005)
PMID: 16141327

Function and Biology Details

Reaction catalysed: 
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 34.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05089 (Residues: 1-322; Coverage: 100%)
Gene name: ARG1
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

2 bound ligands:
Ligand MN 4 x MN
Ligand ABH 2 x ABH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P3
Unit cell:
a: 91.422Å b: 91.422Å c: 69.637Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
not available not available 0.152
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Arginase: an emerging key player in the mammalian immune system.
Munder M. (2009)
15 more

26 mentions without citation

Targeting Metalloenzymes for Therapeutic Intervention.
Chen et al. (2019)
25 more