› 2aiq

X-ray diffraction
1.54Å resolution

Crystal structure of benzamidine-inhibited protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix

Released:
DOI: 10.2210/pdb2aiq/pdb
PDB entry 2aiq coloured by chain, front view.
PDB entry 2aiq coloured by chain, side view.
PDB entry 2aiq coloured by chain, top view.
Source organism: Agkistrodon contortrix contortrix
Primary publication:
Thrombomodulin-independent activation of protein C and specificity of hemostatically active snake venom serine proteinases: crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator.
Murakami MT, Arni RK
J Biol Chem 280 39309-15 (2005)
PMID: 16162508

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein C activator Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.13 KDa
Source organism: Agkistrodon contortrix contortrix
UniProt:
  • Canonical: P09872 (Residues: 1-231; Coverage: 100%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

6 bound ligands:
Ligand NAG 3 x NAG
Ligand SO4 1 x SO4
Ligand ACT 1 x ACT
Ligand CL 1 x CL
Ligand BEN 1 x BEN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: C2
Unit cell:
a: 80.516Å b: 63.463Å c: 48.216Å
α: 90° β: 99.85° γ: 90°
R-values:
R R work R free
0.176 0.168 0.191

Quick links

Citations

4 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
3 more

3 mentions without citation

The expanding diversity of serine hydrolases.
Botos et al. (2007)
2 more