› 2alr

X-ray diffraction
2.48Å resolution

ALDEHYDE REDUCTASE

Released:
DOI: 10.2210/pdb2alr/pdb
PDB entry 2alr coloured by chain, front view.
PDB entry 2alr coloured by chain, side view.
PDB entry 2alr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
El-Kabbani O, Green NC, Lin G, Carson M, Narayana SV, Moore KM, Flynn TG, DeLucas LJ
Acta Crystallogr D Biol Crystallogr 50 859-68 (1994)
PMID: 15299353

Function and Biology Details

Reactions catalysed: 
L-gulonate + NADP(+) = D-glucuronate + NADPH
An alcohol + NADP(+) = an aldehyde + NADPH
L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + NADPH
Glycerol + NADP(+) = D-glyceraldehyde + NADPH
Allyl alcohol + NADP(+) = acrolein + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146963 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldo-keto reductase family 1 member A1 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.49 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14550 (Residues: 2-325; Coverage: 100%)
Gene names: AKR1A1, ALDR1, ALR
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 82.6Å b: 60Å c: 66.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 not available

Quick links

Citations

2 review citations

Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions.
von Itzstein et al. (1996)
1 more

8 mentions without citation

Prediction of catalytic residues using Support Vector Machine with selected protein sequence and structural properties.
Petrova et al. (2006)
7 more