› 2b1a

X-ray diffraction
2.35Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212647 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab 2219, light chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 22.95 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Fab 2219, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Envelope glycoprotein gp160 Chain: P
Molecule details ›
Chain: P
Length: 23 amino acids
Theoretical weight: 2.46 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q90VI2 (Residues: 307-329; Coverage: 3%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 62.716Å b: 96.89Å c: 97.018Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.244
Expression system: Not provided

Quick links

Citations

4 review citations

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.
Kwong et al. (2012)
3 more

8 mentions without citation

Crystal structures of human sulfotransferases: insights into the mechanisms of action and substrate selectivity.
Dong et al. (2012)
7 more