› 2bjn

X-ray diffraction
1.7Å resolution

X-ray Structure of human TPC6

Released:
DOI: 10.2210/pdb2bjn/pdb
PDB entry 2bjn coloured by chain, front view.
PDB entry 2bjn coloured by chain, side view.
PDB entry 2bjn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex.
Kümmel D, Müller JJ, Roske Y, Misselwitz R, Büssow K, Heinemann U
EMBO Rep 6 787-93 (2005)
PMID: 16025134

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trafficking protein particle complex subunit 6B Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86SZ2 (Residues: 1-158; Coverage: 100%)
Gene name: TRAPPC6B
Sequence domains: Transport protein particle (TRAPP) component
Structure domains: Trafficking protein particle complex subunit 3

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 99.423Å b: 57.005Å c: 60.406Å
α: 90° β: 117.16° γ: 90°
R-values:
R R work R free
0.177 0.175 0.209
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The TRAPP complex: insights into its architecture and function.
Sacher et al. (2008)
6 more

7 mentions without citation

The prokaryotic V4R domain is the likely ancestor of a key component of the eukaryotic vesicle transport system.
Podar et al. (2008)
6 more