› 2c1p

X-ray diffraction
2Å resolution

Fab-fragment of enantioselective antibody complexed with finrozole

Released:
DOI: 10.2210/pdb2c1p/pdb
PDB entry 2c1p coloured by chain, front view.
PDB entry 2c1p coloured by chain, side view.
PDB entry 2c1p coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of an enantioselective fab-fragment in free and complex forms.
Parkkinen T, Nevanen TK, Koivula A, Rouvinen J
J Mol Biol 357 471-80 (2006)
PMID: 16427081

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212290 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, L
Molecule details ›
Chains: A, L
Length: 218 amino acids
Theoretical weight: 24.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q58EU8 (Residues: 21-238; Coverage: 100%)
Gene name: Igk
Sequence domains:
Structure domains: Immunoglobulins
IGH-4 PROTEIN Chains: B, H
Molecule details ›
Chains: B, H
Length: 217 amino acids
Theoretical weight: 23.37 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand FNZ 2 x FNZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P212121
Unit cell:
a: 70.815Å b: 87.419Å c: 141.684Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.285
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.
Fleming et al. (2010)
1 more

1 mention without citation

Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces.
Szent-Gyorgyi et al. (2013)