› 2cm6

X-ray diffraction
1.85Å resolution

crystal structure of the C2B domain of rabphilin3A

Released:
DOI: 10.2210/pdb2cm6/pdb
PDB entry 2cm6 coloured by chain, front view.
PDB entry 2cm6 coloured by chain, side view.
PDB entry 2cm6 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A.
Montaville P, Schlicker C, Leonov A, Zweckstetter M, Sheldrick GM, Becker S
J Biol Chem 282 5015-5025 (2007)
PMID: 17166855

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rabphilin-3A Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 19.11 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P47709 (Residues: 519-684; Coverage: 24%)
Gene name: Rph3a
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 40.069Å b: 59.606Å c: 66.385Å
α: 90° β: 103.89° γ: 90°
R-values:
R R work R free
0.198 not available 0.268
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

DOC2B, C2 domains, and calcium: A tale of intricate interactions.
Friedrich et al. (2010)
1 more

3 mentions without citation

The PIP2 binding mode of the C2 domains of rabphilin-3A.
Montaville et al. (2008)
2 more