› 2d2x

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
D-glucose-6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193404 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-deoxy-scyllo-inosose synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 368 amino acids
Theoretical weight: 40.79 KDa
Source organism: Niallia circulans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9S5E2 (Residues: 1-368; Coverage: 100%)
Gene name: btrC
Sequence domains: 3-dehydroquinate synthase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CO 4 x CO
Ligand SO3 2 x SO3
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P21
Unit cell:
a: 80.51Å b: 70.35Å c: 82.984Å
α: 90° β: 117.84° γ: 90°
R-values:
R R work R free
0.207 0.191 0.228
Expression system: Escherichia coli

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Citations

3 review citations

2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways.
Park et al. (2013)
2 more

3 mentions without citation

De novo synthesis of a sunscreen compound in vertebrates.
Osborn et al. (2015)
2 more