› 2du2

X-ray diffraction
2.1Å resolution

Crystal Structure Analysis of the L-Lactate Oxidase

Released:
DOI: 10.2210/pdb2du2/pdb
PDB entry 2du2 coloured by chain, front view.
PDB entry 2du2 coloured by chain, side view.
PDB entry 2du2 coloured by chain, top view.
Source organism: Aerococcus viridans
Primary publication:
The crystal structure of L-lactate oxidase from Aerococcus viridans at 2.1A resolution reveals the mechanism of strict substrate recognition.
Umena Y, Yorita K, Matsuoka T, Kita A, Fukui K, Morimoto Y
Biochem Biophys Res Commun 350 249-56 (2006)
PMID: 17007814

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175022 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate oxidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 374 amino acids
Theoretical weight: 40.98 KDa
Source organism: Aerococcus viridans
UniProt:
  • Canonical: Q44467 (Residues: 1-374; Coverage: 100%)
Sequence domains: FMN-dependent dehydrogenase
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand FMN 4 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: I422
Unit cell:
a: 191.096Å b: 191.096Å c: 194.497Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.199

Quick links

Citations

1 review citation

Microbial lactate utilization: enzymes, pathogenesis, and regulation.
Jiang et al. (2014)
15 other articles

5 mentions without citation

Structure of human glycolate oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole.
Bourhis et al. (2009)
4 more