› 2e26

X-ray diffraction
2Å resolution

Crystal structure of two repeat fragment of reelin

Released:
DOI: 10.2210/pdb2e26/pdb
PDB entry 2e26 coloured by chain, front view.
PDB entry 2e26 coloured by chain, side view.
PDB entry 2e26 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.
Yasui N, Nogi T, Kitao T, Nakano Y, Hattori M, Takagi J
Proc Natl Acad Sci U S A 104 9988-93 (2007)
PMID: 17548821

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178823 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Reelin Chain: A
Molecule details ›
Chain: A
Length: 725 amino acids
Theoretical weight: 81.35 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q60841 (Residues: 1948-2661; Coverage: 21%)
Gene names: Reln, Rl
Sequence domains: Reelin subrepeat B
Structure domains: Galactose-binding domain-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
4 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 4 x CA
Ligand ZN 2 x ZN
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 61.008Å b: 70.953Å c: 94.769Å
α: 90° β: 93.61° γ: 90°
R-values:
R R work R free
0.219 0.179 0.219
Expression system: Cricetulus griseus

Quick links

Citations

11 review citations

New Insights into Reelin-Mediated Signaling Pathways.
Lee et al. (2016)
10 more

11 mentions without citation

Structural Insights into Reelin Function: Present and Future.
Ranaivoson et al. (2016)
10 more