› 2epf

X-ray diffraction
2.3Å resolution

Crystal Structure of Zinc-Bound Pseudecin From Pseudechis Porphyriacus

Released:
DOI: 10.2210/pdb2epf/pdb
PDB entry 2epf coloured by chain, front view.
PDB entry 2epf coloured by chain, side view.
PDB entry 2epf coloured by chain, top view.
Source organism: Pseudechis porphyriacus
Primary publication:
Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain.
Suzuki N, Yamazaki Y, Brown RL, Fujimoto Z, Morita T, Mizuno H
Acta Crystallogr D Biol Crystallogr 64 1034-42 (2008)
PMID: 18931410

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-183817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine-rich venom protein pseudecin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 210 amino acids
Theoretical weight: 23.62 KDa
Source organism: Pseudechis porphyriacus
UniProt:
  • Canonical: Q8AVA3 (Residues: 29-238; Coverage: 96%)
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 5 x ZN
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 60.077Å b: 62.344Å c: 246.943Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.219 0.277

Quick links

Citations

5 review citations

The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites.
Williams et al. (2019)
4 more

4 mentions without citation

Cysteine-Rich Secretory Proteins (CRISPs) From Venomous Snakes: An Overview of the Functional Diversity in A Large and Underappreciated Superfamily.
Tadokoro et al. (2020)
3 more