› 2esa

X-ray diffraction
1.9Å resolution

GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA

Released:
DOI: 10.2210/pdb2esa/pdb
PDB entry 2esa coloured by chain, front view.
PDB entry 2esa coloured by chain, side view.
PDB entry 2esa coloured by chain, top view.
Source organism: Canis lupus familiaris
Entry authors: Immormino RM, Metzger IV LE, Gewirth DT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoplasmin Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.44 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41148 (Residues: 69-337; Coverage: 30%)
Gene names: GRP94, HSP90B1, HSPC4, TRA1
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

3 bound ligands:
Ligand GDM 1 x GDM
Ligand PG4 1 x PG4
Ligand PGE 2 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 47.33Å b: 66.39Å c: 75.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 0.213
Expression system: Escherichia coli BL21(DE3)

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