› 2ewl

Solution NMR

Solution structure of the C-terminal domain (monomer) of the HPV45 oncoprotein E7

Released:
DOI: 10.2210/pdb2ewl/pdb
PDB entry 2ewl coloured by chain, ensemble of 15 models, front view.
PDB entry 2ewl coloured by chain, ensemble of 15 models, side view.
PDB entry 2ewl coloured by chain, ensemble of 15 models, top view.
Source organism: human papillomavirus 45
Primary publication:
Solution structure of the partially folded high-risk human papilloma virus 45 oncoprotein E7.
Ohlenschläger O, Seiboth T, Zengerling H, Briese L, Marchanka A, Ramachandran R, Baum M, Korbas M, Meyer-Klaucke W, Dürst M, Görlach M
Oncogene 25 5953-9 (2006)
PMID: 16636661

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein E7 Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.31 KDa
Source organism: human papillomavirus 45
Expression system: Escherichia coli
UniProt:
  • Canonical: P21736 (Residues: 55-106; Coverage: 49%)
Gene name: E7
Sequence domains: E7 protein, Early protein
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry/simulated annealing by CYANA, energy minimisation by OPAL
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Intrinsic disorder and functional proteomics.
Radivojac et al. (2007)
14 more

10 mentions without citation

Evolution of human papillomavirus carcinogenicity.
Van Doorslaer et al. (2010)
9 more