Function and Biology Details
Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Peptidase C14A, caspase catalytic domain
- Peptidase C14, caspase non-catalytic subunit p10
- Peptidase family C14A, cysteine active site
- Peptidase family C14A, His active site
- Peptidase C14, caspase domain
- Peptidase C14, p20 domain
- Caspase-like domain superfamily
- Baculovirus p35 superfamily
1 more domain
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Early 35 kDa protein and Caspase-8 subunit p10 (preferred)
PDBe Complex ID:
PDB-CPX-139942 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 32-ID
Spacegroup:
C2221
Expression system: Escherichia coli