› 2g17

X-ray diffraction
2.3Å resolution

The structure of N-acetyl-gamma-glutamyl-phosphate reductase from Salmonella typhimurium.

Released:
DOI: 10.2210/pdb2g17/pdb
PDB entry 2g17 coloured by chain, front view.
PDB entry 2g17 coloured by chain, side view.
PDB entry 2g17 coloured by chain, top view.
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Entry authors: Cuff ME, Zhou M, Abdullah J, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed: 
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-L-glutamyl 5-phosphate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-acetyl-gamma-glutamyl-phosphate reductase Chain: A
Molecule details ›
Chain: A
Length: 337 amino acids
Theoretical weight: 36.4 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8ZKL8 (Residues: 1-334; Coverage: 100%)
Gene names: STM4121, argC
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 10 x SO4
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6422
Unit cell:
a: 165.001Å b: 165.001Å c: 105.778Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.17 0.193
Expression system: Escherichia coli BL21(DE3)

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