› 2gjt

X-ray diffraction
2.15Å resolution

Crystal structure of the human receptor phosphatase PTPRO

Released:
DOI: 10.2210/pdb2gjt/pdb
PDB entry 2gjt coloured by chain, front view.
PDB entry 2gjt coloured by chain, side view.
PDB entry 2gjt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
OpenAccess logo Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase O Chains: A, B
Molecule details ›
Chains: A, B
Length: 295 amino acids
Theoretical weight: 34.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16827 (Residues: 915-1208; Coverage: 25%)
Gene names: GLEPP1, PTPRO, PTPU2
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand CL 6 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P65
Unit cell:
a: 131.06Å b: 131.06Å c: 77.53Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.179 0.234
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

6 mentions without citation

Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr et al. (2009)
5 more