› 2hdc

Solution NMR

STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX

Released:
DOI: 10.2210/pdb2hdc/pdb
PDB entry 2hdc coloured by chain, ensemble of 20 models, front view.
PDB entry 2hdc coloured by chain, ensemble of 20 models, side view.
PDB entry 2hdc coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex.
Jin C, Marsden I, Chen X, Liao X
J Mol Biol 289 683-90 (1999)
PMID: 10369754

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115337 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Forkhead box protein D3 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.41 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q63245 (Residues: 2-98; Coverage: 96%)
Gene names: Foxd3, Hfh2
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
DNA (5'-D(P*GP*CP*TP*TP*AP*AP*AP*AP*TP*AP*AP*CP*AP*AP*TP*AP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 17 nucleotides
Theoretical weight: 5.19 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
DNA (5'-D(P*GP*TP*AP*TP*TP*GP*TP*TP*AP*TP*TP*TP*TP*AP*AP*GP*C)-3') Chain: C
Molecule details ›
Chain: C
Length: 17 nucleotides
Theoretical weight: 5.22 KDa
Source organism: Rattus norvegicus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Not provided

Quick links

Citations

9 review citations

Forkhead transcription factors: key players in development and metabolism.
Carlsson et al. (2002)
8 more

4 mentions without citation

Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations.
Dai et al. (2021)
3 more