› 2he8

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldo-keto reductase family 1 member C21 Chains: A, B
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 36.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q91WR5 (Residues: 1-323; Coverage: 100%)
Gene name: Akr1c21
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

3 bound ligands:
Ligand ACT 4 x ACT
Ligand BME 3 x BME
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 98.06Å b: 94.95Å c: 69.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.198 0.241
Expression system: Escherichia coli

Quick links

Citations

11 citation in other articles

17α-estradiol is generated locally in the male rat brain and can regulate GAD65 expression and anxiety.
Ikeda et al. (2015)
10 more

1 mention without citation

High-resolution structure of AKR1a4 in the apo form and its interaction with ligands.
Faucher et al. (2012)