› 2hek

X-ray diffraction
2Å resolution

Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.

Released:
DOI: 10.2210/pdb2hek/pdb
PDB entry 2hek coloured by chain, front view.
PDB entry 2hek coloured by chain, side view.
PDB entry 2hek coloured by chain, top view.
Source organism: Aquifex aeolicus
Primary publication:
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus.
Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH
Acta Crystallogr Sect F Struct Biol Cryst Commun 63 369-74 (2007)
PMID: 17565173

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 371 amino acids
Theoretical weight: 44.19 KDa
Source organism: Aquifex aeolicus
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: O67745 (Residues: 1-371; Coverage: 100%)
Gene name: aq_1910
Sequence domains:
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand PO4 4 x PO4
Ligand ZN 2 x ZN
Ligand CL 5 x CL
Ligand GDP 2 x GDP
Ligand GOL 8 x GOL
Ligand BR 1 x BR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2221
Unit cell:
a: 107.687Å b: 144.413Å c: 144.677Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.22
Expression system: Escherichia coli K-12

Quick links

Citations

1 citations in other articles

Mechanism of allosteric activation of SAMHD1 by dGTP.
Ji et al. (2013)

7 mentions without citation

Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.
Beloglazova et al. (2013)
6 more