› 2iep

X-ray diffraction
2.2Å resolution

Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK

Released:
DOI: 10.2210/pdb2iep/pdb
PDB entry 2iep coloured by chain, front view.
PDB entry 2iep coloured by chain, side view.
PDB entry 2iep coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK.
Stiegler AL, Burden SJ, Hubbard SR
J Mol Biol 364 424-33 (2006)
PMID: 17011580

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo trimer
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-178971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Muscle, skeletal receptor tyrosine protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 20.95 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62838 (Residues: 22-212; Coverage: 23%)
Gene name: Musk
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 77.608Å b: 118.004Å c: 57.785Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.258
Expression system: Spodoptera frugiperda

Quick links

Citations

15 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
14 more

7 mentions without citation

Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.
Hubbard et al. (2013)
6 more