› 2int

X-ray diffraction
2.35Å resolution

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4

Released:
DOI: 10.2210/pdb2int/pdb
PDB entry 2int coloured by chain, front view.
PDB entry 2int coloured by chain, side view.
PDB entry 2int coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of recombinant human interleukin-4.
Walter MR, Cook WJ, Zhao BG, Cameron RP, Ealick SE, Walter RL, Reichert P, Nagabhushan TL, Trotta PP, Bugg CE
J Biol Chem 267 20371-6 (1992)
PMID: 1400355

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-4 Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Sequence domains: Interleukin 4
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 91.8Å b: 91.8Å c: 46.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.232 not available
Expression system: Not provided

Quick links

Citations

14 review citations

Alternative activation of macrophages: an immunologic functional perspective.
Martinez et al. (2009)
13 more

3 mentions without citation

Quantum-mechanical calculations on molecular substructures involved in nanosystems.
Szefler et al. (2014)
2 more