› 2jcp

X-ray diffraction
1.3Å resolution

The hyaluronan binding domain of murine CD44

Released:
DOI: 10.2210/pdb2jcp/pdb
PDB entry 2jcp coloured by chain, front view.
PDB entry 2jcp coloured by chain, side view.
PDB entry 2jcp coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction.
Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG
Nat Struct Mol Biol 14 234-9 (2007)
PMID: 17293874

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD44 antigen Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 17.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P15379 (Residues: 22-174; Coverage: 20%)
Gene names: Cd44, Ly-24
Sequence domains: Extracellular link domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 30.726Å b: 82.097Å c: 32.336Å
α: 90° β: 117.92° γ: 90°
R-values:
R R work R free
0.158 0.157 0.191
Expression system: Escherichia coli BL21

Quick links

Citations

49 review citations

Role of Extracellular Matrix in Development and Cancer Progression.
Walker et al. (2018)
48 more

4 mentions without citation

Three-dimensional structural aspects of protein-polysaccharide interactions.
Nagae et al. (2014)
3 more