› 2jgp

X-ray diffraction
1.85Å resolution

Structure of the TycC5-6 PCP-C bidomain of the tyrocidine synthetase TycC

Released:
DOI: 10.2210/pdb2jgp/pdb
PDB entry 2jgp coloured by chain, front view.
PDB entry 2jgp coloured by chain, side view.
PDB entry 2jgp coloured by chain, top view.
Source organism: Brevibacillus brevis
Primary publication:
Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase.
Samel SA, Schoenafinger G, Knappe TA, Marahiel MA, Essen LO
Structure 15 781-92 (2007)
PMID: 17637339

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrocidine synthase 3 Chain: A
Molecule details ›
Chain: A
Length: 520 amino acids
Theoretical weight: 58.9 KDa
Source organism: Brevibacillus brevis
Expression system: Escherichia coli
UniProt:
  • Canonical: O30409 (Residues: 5115-5633; Coverage: 8%)
Gene name: tycC
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand DIO 2 x DIO
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P43212
Unit cell:
a: 84.973Å b: 84.973Å c: 164.969Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.208 0.238
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Nonribosomal Peptide Synthesis-Principles and Prospects.
Süssmuth et al. (2017)
21 more

19 mentions without citation

Structural insights into nonribosomal peptide enzymatic assembly lines.
Koglin et al. (2009)
18 more