2jy0

Solution NMR

Solution NMR structure of HCV NS2 protein, membrane segment (1-27)

Released:

Function and Biology Details

Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-194373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protease NS2 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.84 KDa
Source organism: Hepatitis C virus (isolate Con1)
Expression system: Not provided
UniProt:
  • Canonical: Q9WMX2 (Residues: 810-836; Coverage: 1%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided