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Solution NMR

Solution structure of the folded domain of intermediate IIIb of Tick Carboxypeptidase Inhibitor

Released:
DOI: 10.2210/pdb2k2z/pdb
PDB entry 2k2z coloured by chain, ensemble of 20 models, front view.
PDB entry 2k2z coloured by chain, ensemble of 20 models, side view.
PDB entry 2k2z coloured by chain, ensemble of 20 models, top view.
Source organism: Rhipicephalus bursa
Primary publication:
The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways.
Arolas JL, Pantoja-Uceda D, Ventura S, Blanco FJ, Aviles FX
J Biol Chem 283 27110-20 (2008)
PMID: 18640980

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177032 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase inhibitor Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.17 KDa
Source organism: Rhipicephalus bursa
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5EPH2 (Residues: 59-97; Coverage: 52%)
Sequence domains: Carboxypeptidase inhibitor I68

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

3 review citations

NMR as a tool to identify and characterize protein folding intermediates.
Neira JL. (2013)
2 more